| Propostes TFM curs 2021-22 |
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| Project: |
Drug screen in induced pluripotent stem cell derived model of Friedreich Ataxia |
| Keywords |
friedreich ataxia; degenerative disease; mitochondria; sensory neurons, induced pluripotent stem cells |
| Supervisor/s |
Fabien Delaspre |
| E-mail |
fabien.delaspre@udl.cat |
| Group |
Bioquímica de l'estrès oxidatiu |
| PhD |
Yes |
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| Project: |
NRG1-ErbBs signalling pathway in C-Type cholinergic synapses of motor neurons: implications in the physiopathology and therapy in animal models of Amiotrophic Lateral Sclerosis. |
| Keywords |
Amyotrophic Lateral Sclerosis, C-bouton, Neuregulin-1, SOD1 |
| Supervisor/s |
Sara Hernandez, Anna Casanovas |
| E-mail |
sara.hernandez@udl.cat |
| Group |
Grup de Patologia Neuromuscular Experimental |
| PhD |
Yes |
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| Project: |
Drug repurposing to tackle Crohn’s disease progression: Screening of a FDA-approved drug library against TNF-α-driven cell death in autophagy-deficient genetic models |
| Keywords |
Crohn, Autophagy, cell death, FDA-approved drugs, TNF-alpha, inflammation |
| Supervisor/s |
Judit Ribas i Fortuny |
| E-mail |
judit.ribas@udl.cat |
| Group |
Farmacologia de l’estrés Cel·lular (Unitat de Farmacologia) |
| PhD |
Yes |
| |
| Project: |
Modelling metastasis in adult Drosophila: Identification of the mechanisms underlying successful cell migration |
| Keywords |
Drosophila, metastasis, colorectal cancer, EMT, Snail |
| Supervisor/s |
Andreu Casali |
| E-mail |
andreu.casali@udl.cat |
| Group |
Drosophila models of disease |
| PhD |
Yes |
| |
| Project: |
Targeting calcium signaling against glioblastoma |
| Keywords |
autophagy, ER stress, hypoxia, neurospheres, patient-derived cultures |
| Supervisor/s |
Judit Herreros / Carles Cantí |
| E-mail |
judit.herreros@udl.cat; carles.canti@udl.cat |
| Group |
Senyalització per calci |
| PhD |
Yes |
| |
| Project: |
Spinal Muscular Atrophy: molecular mechanisms and new therapeutic strategies |
| Keywords |
human iPSC motoneuron differentiation, survival motor neuron protein, intracellular survival/death pathways, autophagy |
| Supervisor/s |
Rosa M Soler/Ana Garcerá |
| E-mail |
rosa.soler@udl.cat; ana.garcera@udl.cat |
| Group |
Neuronal Signaling Unit |
| PhD |
Yes |
| |
| Project: |
Study design simulations |
| Keywords |
study design - computational simulations - R - Shiny |
| Supervisor/s |
Ester Vilaprinyó Terré |
| E-mail |
ester.vilaprinyo@udl.cat |
| Group |
Biología de sistemas y métodos estadísticos para la investigación |
| PhD |
Yes |
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| Project: |
Identification and validation of candidate genes involved in cellular senescence by a CRISPR/Cas9 screening |
| Keywords |
Cellular Senescence, CRISPR/Cas9 |
| Supervisor/s |
Supervisor/s: Mario Encinas |
| E-mail |
mario.encinas@udl.cat |
| Group |
Developmental and Oncogenic Signaling |
| PhD |
Yes |
| |
| Project: |
Membrane contact sites in the pathophysiology of age-related neurodegenerative diseases |
| Keywords |
ER stress, mitochondria, respirometry, motor neuron, lipid metabolism |
| Supervisor/s |
Manuel Portero-Otin |
| E-mail |
manuel.portero@udl.cat |
| Group |
Metabolic Pathophysiology |
| PhD |
Yes |
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|
| Project: |
Iron as a determining factor in the participation of sphingolipid metabolism in the regulation of autophagy. |
| Keywords |
yeast, iron, sphingolipid, autophagy |
| Supervisor/s |
Mª Angeles de la Torre |
| E-mail |
mariaangeles.delatorre@udl.cat |
| Group |
Cell Signalling in Yeast |
| PhD |
Yes |
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|
| Project: |
Determinació del paper de BCAT1 en la carcinogènesi endometrial |
| Keywords |
Càncer endometri, BCAT1, Cultius 3D, CRISPR/Cas9 lentivirus, assaig molecular in vitro |
| Supervisor/s |
Núria Eritja |
| E-mail |
eritja@irblleida.cat |
| Group |
Patologia oncològica (https://www.irblleida.org/ca/recerca/16/patologia-oncologica ) |
| PhD |
Yes |
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|
| Project: |
Precision medicine in patients with sleep apnea and acute coronary syndrome: Predictive model of response to treatment |
| Keywords |
Sleep apnea; Personalized Medicine; Biomarkers. |
| Supervisor/s |
Manuel Sánchez de la Torre |
| E-mail |
sanchezdelatorre@gmail.com |
| Group |
Precision Medicine in Chronic Diseases Group (http://www.irblleida.org/en/research/40/precision-medicine-in-chronic-diseases-group) |
| PhD |
Yes |
| |
|
| Project: |
Role of cyclin D3 in the regulation of mitochondrial function and oxidative stress in pancreatic beta cells. Studies in autoimmune diabetes. |
| Keywords |
Autoimmune diabetes, cyclin D3, redox-balance, inflammation, apoptosis |
| Supervisor/s |
Conchi Mora |
| E-mail |
conchi.mora@udl.cat |
| Group |
Grup de Recerca en Immunologia i Immunopatologia |
| PhD |
Yes |
| |
| Project: |
Pathogenic mechanisms underlying Spinal Muscular Atrophy: the role of neuroinflamation |
| Keywords |
SMA, motoneuron, glia, spinal cord |
| Supervisor/s |
Jordi Calderó/Olga Tarabal |
| E-mail |
jordi.caldero@udl.cat |
| Group |
Grup de Patologia Neuromuscular Experimental |
| PhD |
Yes |
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|
| Project: |
Dissecting the role of SNCA in the development of experimental acute kidney injury. |
| Keywords |
SNCA, kidney, proximal tubular cells, inflammation, oxidative stress |
| Supervisor/s |
Milica Bozic/Jose M. Valdivielso |
| E-mail |
mbozic@irblleida.cat |
| Group |
Vascular and Renal Translational Research Group |
| PhD |
Yes |
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