Project: |
Spinal Muscular Atrophy: molecular mechanisms and new therapeutic strategies |
Keywords |
human iPSC motoneuron differentiation, survival motor neuron protein, intracellular survival/death pathways, autophagy |
Supervisor/s |
Rosa M Soler/Ana Garcerá |
E-mail |
rosa.soler@udl.cat; ana.garcera@udl.cat |
Group |
Neuronal Signaling Unit |
PhD |
Yes |
|
Project: |
Mechanisms involved in the role of EndoG in the development and metabolism of the heart. Relationship of ENDOG and other apoptotic genes with cardiac pathophysiology (EndogHeart) |
Keywords |
EndoG, heart, cardiomyocyte, cell signaling |
Supervisor/s |
Daniel Sanchis/Marta Llovera |
E-mail |
daniel.sanchis@udl.cat; marta.llovera@udl.cat |
Group |
Cell Signaling and Apoptosis Group |
PhD |
Yes |
|
Project: |
Role of cyclin D3 in the regulation of mitochondrial function and oxidative stress in pancreatic beta cells. Studies in autoimmune diabetes. |
Keywords |
Autoimmune diabetes, cyclin D3, redox-balance, inflammation, apoptosis |
Supervisor/s |
Conchi Mora |
E-mail |
conchi.mora@udl.cat |
Group |
Grup de Recerca en Immunologia i Immunopatologia |
PhD |
Yes |
|
Project: |
NRG1-ErbBs signalling pathway in C-Type cholinergic synapses of motor neurons: implications in the physiopathology and therapy in animal models of Amiotrophic Lateral Sclerosis. |
Keywords |
Amyotrophic Lateral Sclerosis, C-bouton, Neuregulin-1, SOD1 |
Supervisor/s |
Sara Hernandez, Anna Casanovas |
E-mail |
sara.hernandez@udl.cat. |
Group |
Grup de Patologia Neuromuscular Experimental |
PhD |
Yes |
|
Project: |
Calcium signalling in human derived motoneuron from Spinal Muscular Atrophy patients (SMA). |
Keywords |
Motoneuron, Human induced pluripotent stem cell (iPSC), SMA |
Supervisor/s |
Olga Tarabal/Jordi Calderó |
E-mail |
olga.tarabal@mex.udl.cat |
Group |
Grup de Patologia Neuromuscular Experimental |
PhD |
Yes |
|
Project: |
Modelling metastasis in adult Drosophila: Identification of the mechanisms underlying successful cell migration |
Keywords |
Drosophila, metastasis, colorectal cancer, EMT, Snail |
Supervisor/s |
Andreu Casali |
E-mail |
andreu.casali@udl.cat |
Group |
Drosophila models of disease |
PhD |
Yes |
|
Project: |
Targeting calcium signaling against glioblastoma |
Keywords |
autophagy, ER stress, hypoxia, neurospheres, patient-derived cultures |
Supervisor/s |
Judit Herreros / Carles Cantí |
E-mail |
judit.herreros@udl.cat; carles.canti@udl.cat |
Group |
Senyalització per calci |
PhD |
Yes |
|
Project: |
ANALYSIS OF MITOCHONDRIAL IMPAIRMENT IN THE I151F MOUSE MODEL OF FRIEDREICH ATAXIA AND THE ROLE OF SIRT3 |
Keywords |
Friedriech ataxia, mitochondria, mPTP, calcium metabolism, oxidative stress, SirT3 |
Supervisor/s |
Elisa Cabiscol |
E-mail |
elisa.cabiscol@udl.cat |
Group |
Bioquímica de l'estrès oxidatiu |
PhD |
Yes |
|
Project: |
Adipose Tissue Metabolic Flexibility in Obesity and chronic degenerative diseases |
Keywords |
Obesity, Adipose Tissue, Metabolism |
Supervisor/s |
Jose Serrano |
E-mail |
josecarlos.serrano@udl.cat |
Group |
Metabolic Physiopathology |
PhD |
Yes |
|
Project: |
Drug screen in induced pluripotent stem cell derived models of Friedreich Ataxia |
Keywords |
friedreich ataxia; degenerative disease; mitochondria; sensory neurons, cardiomyocytes |
Supervisor/s |
Fabien Delaspre |
E-mail |
fabien.delaspre@udl.cat |
Group |
Bioquímica de l'estrès oxidatiu |
PhD |
Yes |
|
Project: |
Identification and validation of candidate genes involved in cellular senescence by a CRISPR/Cas9 screening |
Keywords |
Cellular Senescence, CRISPR/Cas9 |
Supervisor/s |
Supervisor/s: Mario Encinas |
E-mail |
mario.encinas@udl.cat |
Group |
Developmental and Oncogenic Signaling |
PhD |
Yes |