| Glycogen accumulation modulates lifespan in a mouse model of amyotrophic lateral sclerosis. |
2024 |
Brewer MK; Torres P; Ayala V; Portero-Otin M; Pamplona R; Andrés-Benito P; Ferrer I; Guinovart JJ; Duran J. |
Article d'investigació |
| Gut microbes shape microglia and cognitive function during malnutrition |
2022 |
Bauer KC, York EM, Cirstea MS, Radisavljevic N, Petersen C, Huus KE, Brown EM, Bozorgmehr T, Berdún R, Bernier LP, Lee AHY, Woodward SE, Krekhno Z, Han J, Hancock REW, Ayala V, MacVicar BA, Finlay BB. |
Article d'investigació |
| Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective. |
2022 |
Bauer KC, Littlejohn PT, Ayala V, Creus-Cuadros A, Finlay BB. |
Review |
| A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers. |
2022 |
Torres, P.; Anerillas, C.; Ramírez Núñez, O.; Fernàndez, A.; Encinas, M.; Povedano, M.; Andrés Benito, P.; Ferrer, I.; Ayala, V.; Pamplona, R.; Portero Otín, M. |
Article d'investigació |
| The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer's Disease Pathology |
2021 |
Jové, M.; Mota Martorell, N.; Torres, P.; Ayala, V.; Portero Otin, M.; Ferrer, I.; Pamplona, R. |
Review |
| Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Applied in Old Age |
2021 |
Jové, M.; Cabré, R.; Mota Martorell, N.; Martin Garí, M.; Obis, È.; Ramos, P.; Canales, I.; Galo Licona, J.D.; Sol, J.; Nogueras, L.; Torres, P.; Portero Otín, M.; Ayala, V.; Ferrer, I.; Pamplona, R. |
Article d'investigació |
| Nuclear lipidome is altered in amyotrophic lateral sclerosis: A pilot study |
2021 |
Ramírez Nuñez, O.; Jové, M.; Torres, P.; Sol, J.; Fontdevila, L.; Romero Guevara, R.; Andrés Benito, P.; Ayala, V.; Rossi, C.; Boada, J.; Povedano, M.; Ferrer, I.; Pamplona, R.; Portero Otin, M. |
Article d'investigació |
| Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression |
2021 |
Sol, J.; Jové, M.; Povedano, M.; Sproviero, W.; Domínguez, R.; Piñol Ripoll, G.; Romero Guevara, R.; Hye, A.; Al Chalabi, A.; Torres, P.; Andres Benito, P.; Area Gómez, E.; Pamplona, R.; Ferrer, I.; A |
Article d'investigació |
| Gender-specific beneficial effects of docosahexaenoic acid dietary supplementation in G93A-SOD1 amyotrophic lateral sclerosis mice |
2020 |
Torres P; Cacabelos D; Pairada J; Bauer KC; Boada J; Fontdevila L; Rossi C; Povedano M; Ferrer I; Pamplona R; Finlay BB; Portero-Otín M; Ayala V |
Article d'investigació |
| Dietary intervention reverses fatty liver and altered gut microbiota during early-life undernutrition. |
2020 |
Bauer, K.C.; Huus, K.E.; Brown, E.M.; Bozorgmehr, T.; Petersen, .CN.; Cirstea, M.S.; Woodward, S.E.; McCoy, J.; Hun, J.; Pamplona, R.; Ayala, V.; Finlay, B.B. |
Article d'investigació |
| The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity. |
2020 |
Jove, M.; Mota-Martorell, N.; Pradas, I.; Martin-Gari, M.; Ayala, V.; Pamplona, R. |
Review |
| Succination of protein thiols in human brain aging. |
2020 |
Jove, M.; Pradas, I.; Mota-Martorell, N.; Cabre, R.; Ayala, V.; Ferrer, I.; Pamplona, R. |
Article d'investigació |
| Selected cryptic exons accumulate in hippocampal cell nuclei in Alzheimer's disease with and without associated TDP-43 proteinopathy |
2020 |
Torres, P.; Andrés Benito, P.; Fernàndez Bernal, A.; Ricart, M.; Ayala, V.; Pamplona, R.; Ferrer, I.; Portero Otin, M. |
Article d'investigació |
| Effects of aging and methionine restriction on rat kidney metabolome. |
2019 |
Pradas I; Jove M; Cabre R; Ayala V; Mota-Martorell N; Pamplona R. |
Article d'investigació |
| Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue. |
2018 |
Torres, P.; Ramírez-Núñez, O.; Romero-Guevara, R.; Barés, G.; Granado-Serrano, A.B.; Ayala, V.; Boada, J.; Fontdevila, L.; Povedano, M.; Sanchís, D.; Pamplona, R.; Ferrer, I.; Portero-Otín, M. |
Article d'investigació |
| Lipidomics Reveals a Tissue-Specific Fingerprint |
2018 |
Pradas I; Huynh K; Cabré R; Ayala V; Meikle PJ; Jové M; Pamplona R. |
Article d'investigació |
| Lipid profile in human frontal cortex is sustained throughout healthy adult lifespan to decay at advanced ages |
2018 |
Cabré R; Naudí A; Dominguez-Gonzalez M; Jové M; Ayala V; Mota-Martorell N; Pradas I; Nogueras L; Rué M; Portero-Otín M; Ferrer I; Pamplona R |
Article d'investigació |
| Specific metabolomics adaptations define a differential regional vulnerability in the human cerebral cortex. |
2017 |
Cabré R; Jové M; Naudí A; Ayala V; Piñol-Ripoll G; Gil-Villar MP; Dominguez-Gonzalez M; Obis E; Berdun R; Mota-Martorell N; Portero-Otin M; Ferrer I: Pamplona R. |
Capítol de llibre docent |
| Sixty years-old is the breakpoint of the human frontal cortex aging. |
2017 |
Cabré R; Naudí A; Dominguez-Gonzalez M; Ayala V; Jové M; Mota-Martorell N; Piñol-Ripoll G;Gil-Villar MP; Rué M; Portero-Otín M; Ferrer I; Pamplona R |
Article d'investigació |
| Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system |
2017 |
Naudí A, Cabré R, Dominguez-Gonzalez M, Ayala V, Jové M, Mota-Martorell N, Piñol-Ripoll G, Gil-Villar MP, Rué M, Portero-Otín M, Ferrer I, Pamplona R. |
Article d'investigació |
| Membrane lipid unsaturation as physiological adaption to animal longevity. |
2017 |
Naudí A, Jové M, Ayala V, Portero-Otin M, Barja G, Pamplona R. |
Capítol de llibre docent |
| Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS |
2016 |
Cacabelos D; Ramírez-Núñez O; Granado-Serrano AB; Torres P; Ayala V; Moiseeva V; Povedano M; Ferrer I; Pamplona R; Portero-Otin M; Boada J. |
Article d'investigació |
| Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis |
2016 |
Cacabelos D; Ayala V; Granado-Serrano AB; Jové M; Torres P; Boada J; Cabré R; Ramírez-Núñez O; Gonzalo H; Soler-Cantero A; Serrano JC; Bellmunt MJ, Romero MP; Motilva MJ; Nonaka T; Hasegawa M; Ferrer |
Article d'investigació |
| Specific metabolomics adaptations define a differential regional vulnerability in the adult human cerebral cortex |
2016 |
Cabré R; Jové M; Naudí A; Ayala V; Piñol-Ripoll G; Gil-Villar MP; Dominguez-Gonzalez M; Obis E; Berdun R; Mota-Martorell N; Portero-Otin M; Ferrer I; Pamplona R. |
Article d'investigació |
| Lipidomics of Human Brain Aging and Alzheimer's Disease Pathology |
2015 |
Naudí A, Cabré R, Jové M, Ayala V, Gonzalo H, Portero-Otín M, Ferrer I, Pamplona R. |
Review |
| Target of rapamycin activation predicts lifespan in fruit flies |
2015 |
Scialo F, Sriram A, Naudí A, Ayala V, Jové M, Pamplona R, Sanz A. |
Article d'investigació |
| Do primary health centres and hospitals contribute equally towards achievement of the transversal clinical competencies of medical students? Performance on the Objective Structured Clinical Examinatio |
2015 |
Soler-González J; Buti M; Boada J; Ayala V; Peñascal E; Rodriguez T; GERDS group. |
Article en premsa |
| Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner |
2014 |
Cacabelos D, Ayala V, Ramirez-Nuñez O, Granado-Serrano AB, Boada J, Serrano JCE, Cabre R, Nadal-Rey G, Bellmunt MJ, Ferrer I, Pamplona R, Portero-Otin M. |
Article d'investigació |
| Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system. |
2013 |
Keipert S; Ost M; Chadt A; Voigt A; Ayala V; Portero-Otin M; Pamplona R; Al-Hasani H; Klaus S. |
Article d'investigació |
| Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions |
2013 |
Naudi A, Jove M, Ayala V, Cabre R, Portero-Otin M, Pamplona R. |
Review |
| Specific Lipidome Signatures in Central Nervous System from Methionine-Restricted Mice |
2013 |
Jové M, Ayala V, Ramírez-Núñez O, Naudí A, Cabré R, Spickett CM, Portero-Otín M, Pamplona R. |
Article d'investigació |
| Formation of S-(Carboxymethyl)-cysteine in rat liver mitochondrial proteins. Effects of caloric and methionine restriction. |
2013 |
Naudí A, Jové M, Cacabelos D, Ayala V, Cabré R, Caro P; Gómez J, Portero-Otín M, Barja G, Pamplona R |
Article d'investigació |
| A study of selective neuronal vulnerability in the human central nervous system |
2013 |
Naudí A; Jové M; Ayala V; Cabré R; Portero-Otin M; Ferrer I; Pamplona R. |
Article d'investigació |
| Membrane lipid unsaturation as physiological adaptation to animal longevity |
2013 |
Naudi A; Jove M; Ayala V; Portero-Otin M; Barja G; Pamplona R |
Article d'investigació |
| Estrés oxidativo, vulnerabilidad neuronal selectiva, y enfermedades neurodegenerativas asociadas a la edad. |
2013 |
Naudi A; Jove M; Ayala V; Cacabelos D; Ramírez O; Ferrer I; Portero-Otin M; Pamplona R. |
Capítol de llibre docent |
| Plasma long-chain free fatty acids predict mammalian longevity |
2013 |
Jove M, Naudi A, Aledo JC, Cabre R, Ayala V, Portero-Otin M, Barja G, Pamplona R. |
Article d'investigació |
| Estudio de la vulnerabilidad neuronal selectiva en el sistema nervioso central humano. |
2013 |
Naudi A; Jove M; Ayala V; Cabre R; Portero-Otin M; Ferrer I; Pamplona R. |
Article d'investigació |
| Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters |
2013 |
Jove M, Ayala V, Ramirez-Nuñez O, Serrano JCE, Cassanye A, Arola L, Caimari A, del Bas JM, Crescenti A, Pamplona R, Portero-Otin M. |
Article d'investigació |
| DJ-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster. |
2012 |
Stefanatos R; Sriram A; Kiviranta E; Mohan A; Ayala V; Jacobs HT; Pamplona R; Sanz A. |
Article d'investigació |
| Region specific vulnerability to lipid peroxidation in the human central nervous system. |
2012 |
Naudi A; Jove M; Ayala V; Ramirez O; Cabre R; Prat J; Portero-Otin M; Ferrer I; Pamplona R. |
Capítol de llibre docent |
| Metabolómica Multicompartimental para el Estudio de los Efectos Fisiológicos de Compuestos Activos en Modelos in vivo |
2012 |
Mariona Jové; José CE Serrano; Victòria Ayala; Neus Anglès; Jordi Reguant; José R Morelló; Núria Brunet; Reinald Pamplona; Manuel Portero-Otín |
Article en premsa |
| Region specific vulnerability to lipid peroxidation in the human central nervous system. |
2012 |
Alba Naudí; Mariona Jové; Victòria Ayala; Omar Ramírez; Rosanna Cabré; Joan Prat; Manuel Portero-Otín; Isidre Ferrer; Reinald Pamplona. |
Capítol de llibre docent |
| Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress |
2012 |
Naudí A, Jové M, Ayala V, Cassanye A, Serrano J, Gonzalo H, Boada J, Prat J,Portero-Otín M,Pamplona R |
Review |
| Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart. |
2011 |
Sanchez-Roman I; Gomez A; Gomez J; Suarez H; Sanchez C; Naudi A; Ayala V; Portero-Otin M; Lopez-Torres M; Pamplona R; Barja G. |
Article d'investigació |
| Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS |
2011 |
Ayala V, Granado-Serrano AB, Cacabelos D, Naudí A, Ilieva EV, Boada J, Caraballo-Miralles V, Lladó J, Ferrer I, Pamplona R, Portero-Otin M. |
Article d'investigació |
| Membrane unsaturation, selective neuronal vulnerability, and age-related neurodegenerative diseases. |
2011 |
Naudi A; Jove M; Cacabelos D; Ramirez O; Ayala V; Ilieva EV; Kichev A; Ferrer I; Portero-Otin M; Pamplona R. |
Capítol de llibre d'investigació |
| Multicompartmental LC-Q-TOF-Based Metabonomics as an exploratory tool to identify novel pathways affected by polyphenol-rich diets in mice. |
2011 |
Jove, M; Serrano, JCE; Ortega, N; Ayala, V; Angles, N; Reguant, J ; Morello, JR; Romero, MP ; Motilva, MJ; Prat, J ; Pamplona, R ; Portero-Otin, M |
Article d'investigació |
| Resistencia a la insulina: ¿factor de riesgo o adaptación fisiológica?. |
2011 |
Pamplona R; Serrano J; Boada J; Ayala V; Bellmunt MJ; Espinel A; Delgado MA; Portero-Otin M. |
Capítol de llibre docent |
| Resistencia a la insulina, ¿Factor de riesgo o adaptación fisiológica? |
2011 |
Reinald Pamplona Gras, José Serrano Casasola, Jordi Boada Pallàs, Victoria Ayala Jove, Maria José Bellmunt Curcó, Manuel Portero-Otin, Alberto Espinel González, Marco Antonio Delgado |
Capítol de llibre d'investigació |
| Endogenous toxins associated with life expectancy and aging |
2010 |
Ayala V, Boada J, Serrano J, Portero-Otin M, Pamplona R |
Capítol de llibre docent |
| Pathological aspects of lipid peroxidation |
2010 |
Negre-Salvayre A; Auge N; Ayala V; Basaga H; Boada J; Brenke R; Chapple S; Cohen G; Feher J; Grune T; Lengyel G; Mann GE; Pamplona R; Poli G; Portero-Otin M; Riahi Y; Salvayre R; Sasson S; Serrano J; |
Article d'investigació |
| The beta-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage and increases ERK signaling in heart of C57BL/6 mice. |
2010 |
Sanchez-Roman I, Gomez J, Naudi A, Ayala V, Portero-Otin M, Lopez-Torres M, Pamplona R, Barja G. |
Article d'investigació |
| Glycation of mitochondrial proteins, oxidative stress and aging |
2010 |
Naudí A, Jové M, Ayala V, Portero-Otín M, Pamplona R |
Article d'investigació |
| Protein oxidative damage in diabetes. |
2010 |
Reinald Pamplona; Victoria Ayala; Jordi Boada; Jose Serrano; Manuel Portero-Otín. |
Capítol de llibre d'investigació |
| Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord |
2010 |
Calderó, J.; Brunet, N.; Tarabal, O.; Piedrafita, L.; Hereu, M.; Ayala, V.; Esquerda, J.E. |
Article d'investigació |
| Bases biológicas del proceso de envejecimiento y la longevidad |
2009 |
Naudí A,Caro P, Barja G, Pamplona R |
Capítol de llibre docent |
| Estrés Oxidativo y Lípidos: determinación del índice de peroxidabilidad de los lípidos de membrana y la lesión lipoxidativa a proteínas. |
2009 |
Naudí A,Jové M, Cacabelos D,Ilieva E, Gonzalo H, Serrano J, Ayala V, Boada J, Portero-Otín M, Pamplona R. |
Capítol de llibre docent |
| Oxidación de Macromoléculas, Envejecimiento y Longevidad |
2009 |
Naudí A,Jové M,Ilieva E, Cacabelos D, Gonzalo H, Serrano J,Boada J, Ayala V, Portero-Otín M, Pamplona R. |
Capítol de llibre docent |
| Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex I during forward electron flow and lowers oxidative damage to proteins and mitochondrial DNA |
2009 |
Caro P, Gomez J, Sanchez I, Naudi A, Ayala V, Lopez-Torres M, Pamplona R, Barja G. |
Article d'investigació |
| Maillard reaction versus other nonenzymatic modifications in neurodegenerative processes |
2008 |
Pamplona R, Ilieva E, Ayala V, Bellmunt MJ, Cacabelos D, Dalfo E, Ferrer I, Portero-Otin M |
Article d'investigació |
| Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain |
2007 |
Naudi A, Caro P, Jove M, Gomez J, Boada J, Ayala V, Portero-Otin M, Barja G, Pamplona R |
Article d'investigació |
| Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver |
2007 |
Ayala V, Naudí A, Sanz A, Caro P, Portero-Otin M, Barja G, Pamplona R. |
Article d'investigació |
| The biological basis of the aging process |
2007 |
Naudi A, Jove M, Cacabelos D, Ilieva E, Boada J, Ayala V, Portero-Otin M, Pamplona R |
Review |
| Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis |
2007 |
Ilieva EV, Ayala V, Jove M, Dalfo E, Cacabelos D, Povedano M, Bellmunt MJ, Ferrer I, Pamplona R, Portero-Otin M. |
Article d'investigació |
| Methylglyoxal induces advanced glycation endproduct (AGEs) formation and dysfunction of PDGF receptor-beta. Implications for diabetic atherosclerosis |
2007 |
Cantero AV, Portero-Otin M, Sanson M, Ayala V, Auge N, Elbaz M, Thiers JC, Pamplona R, Salvayre R, Negre-Salvayre A |
Article d'investigació |
| Differential effect of experimental and cold-induced hyperthyoridism on factors inducing rat liver oxidative damage. |
2006 |
Venditti P, Pamplona R, Ayala V, De Rosa R, Caldarone G, DiMeo S. |
Article d'investigació |
| Lesion oxidativa de proteinas de higado y corazon de rata durante el proceso de envejecimiento. |
2006 |
Ayala V, Vasileva E, Fernandez E, Modol MT, Bellmunt MJ, Prat J, Requena JR, Portero-Otin M, Pamplona R. |
Article d'investigació |
| Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease |
2006 |
Muntane G, Dalfo E, Martinez A, Rey MJ, Avila J, Perez M, Portero M, Pamplona R, Ayala V, Ferrer I. |
Article d'investigació |
| Methionine restriction decreases mitochondrial oxygen radical generation and leak and oxidative damage to mitochondrial DNA and proteins. |
2006 |
Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona R and Barja G. |
Article d'investigació |
| Proteins in human brain cortex are modified by oxidation, glycoxidation and lipoxidation: effects of Alzheimer's disease and identification of lipoxidation targets. |
2005 |
Pamplona R, Dalfo E, Ayala MV, Bellmunt MJ, Prat J, Ferrer I, Portero-Otin M. |
Article d'investigació |
| Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate. |
2005 |
Pamplona R, Portero-Otin M, Sanz A, Ayala V, Vasileva E, Barja G. |
Article d'investigació |
| Evidence of oxidative stress in the neocortex in incidental Lewy body disease. |
2005 |
Dalfo E, Portero-Otin M, Ayala MV, Martinez A, Pamplona R, Ferrer I. |
Article d'investigació |
| Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals |
2005 |
Ruiz MC, Ayala V, Portero-Otin M, Requena JR, Barja G, Pamplona R. |
Article d'investigació |
| Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon. |
2004 |
Portero-Otin M, Requena JR, Bellmunt MJ, Ayala V, Pamplona R. |
Article d'investigació |
| Rescue of developing spinal motoneurons from programmed cell death by GABAA agonist muscimol acts by blockade of neuromuscular activity and increased intramuscular nerve branching |
2003 |
Oppenheim RW., Calderó J, Ciutat D, Esquerda JE, Ayala V, Prevette D, Wang S. |
Article d'investigació |
| c-Jun-like immunoreactivity in apoptosis is the result of a crossreaction with neoantigenic sites exposed by caspase-3-mediated proteolysis. |
2002 |
Ribera J, Ayala V, Esquerda JE. |
Article d'investigació |
| Specific association of c-Jun.like immunoreactivity but not c-Jun p39 with normal and induced programmed cell death in the chick embryo |
1999 |
Ayala V, Casas C,Ribera J, Calderó J, Oppenheim RW, Esquerda JE. |
Article d'investigació |
