Master's Final Project Proposals

Project:	Spinal Muscular Atrophy: molecular mechanisms and new therapeutic strategies
Keywords	human iPSC motoneuron differentiation, survival motor neuron protein, intracellular survival/death pathways, autophagy
Supervisor/s	Rosa M Soler/Ana Garcerá
E-mail	rosa.soler@udl.cat; ana.garcera@udl.cat
Group	Neuronal Signaling Unit
PhD	Yes

Project:	Mechanisms involved in the role of EndoG in the development and metabolism of the heart. Relationship of ENDOG and other apoptotic genes with cardiac pathophysiology (EndogHeart)
Keywords	EndoG, heart, cardiomyocyte, cell signaling
Supervisor/s	Daniel Sanchis/Marta Llovera
E-mail	daniel.sanchis@udl.cat; marta.llovera@udl.cat
Group	Cell Signaling and Apoptosis Group
PhD	Yes

Project:	Role of cyclin D3 in the regulation of mitochondrial function and oxidative stress in pancreatic beta cells. Studies in autoimmune diabetes.
Keywords	Autoimmune diabetes, cyclin D3, redox-balance, inflammation, apoptosis
Supervisor/s	Conchi Mora
E-mail	conchi.mora@udl.cat
Group	Grup de Recerca en Immunologia i Immunopatologia
PhD	Yes

Project:	NRG1-ErbBs signalling pathway in C-Type cholinergic synapses of motor neurons: implications in the physiopathology and therapy in animal models of Amiotrophic Lateral Sclerosis.
Keywords	Amyotrophic Lateral Sclerosis, C-bouton, Neuregulin-1, SOD1
Supervisor/s	Sara Hernandez, Anna Casanovas
E-mail	sara.hernandez@udl.cat.
Group	Grup de Patologia Neuromuscular Experimental
PhD	Yes

Project:	Calcium signalling in human derived motoneuron from Spinal Muscular Atrophy patients (SMA).
Keywords	Motoneuron, Human induced pluripotent stem cell (iPSC), SMA
Supervisor/s	Olga Tarabal/Jordi Calderó
E-mail	olga.tarabal@mex.udl.cat
Group	Grup de Patologia Neuromuscular Experimental
PhD	Yes

Project:	Modelling metastasis in adult Drosophila: Identification of the mechanisms underlying successful cell migration
Keywords	Drosophila, metastasis, colorectal cancer, EMT, Snail
Supervisor/s	Andreu Casali
E-mail	andreu.casali@udl.cat
Group	Drosophila models of disease
PhD	Yes

Project:	Targeting calcium signaling against glioblastoma
Keywords	autophagy, ER stress, hypoxia, neurospheres, patient-derived cultures
Supervisor/s	Judit Herreros / Carles Cantí
E-mail	judit.herreros@udl.cat; carles.canti@udl.cat
Group	Senyalització per calci
PhD	Yes

Project:	ANALYSIS OF MITOCHONDRIAL IMPAIRMENT IN THE I151F MOUSE MODEL OF FRIEDREICH ATAXIA AND THE ROLE OF SIRT3
Keywords	Friedriech ataxia, mitochondria, mPTP, calcium metabolism, oxidative stress, SirT3
Supervisor/s	Elisa Cabiscol
E-mail	elisa.cabiscol@udl.cat
Group	Bioquímica de l'estrès oxidatiu
PhD	Yes

Project:	Adipose Tissue Metabolic Flexibility in Obesity and chronic degenerative diseases
Keywords	Obesity, Adipose Tissue, Metabolism
Supervisor/s	Jose Serrano
E-mail	josecarlos.serrano@udl.cat
Group	Metabolic Physiopathology
PhD	Yes

Project:	Drug screen in induced pluripotent stem cell derived models of Friedreich Ataxia
Keywords	friedreich ataxia; degenerative disease; mitochondria; sensory neurons, cardiomyocytes
Supervisor/s	Fabien Delaspre
E-mail	fabien.delaspre@udl.cat
Group	Bioquímica de l'estrès oxidatiu
PhD	Yes

Project:	Identification and validation of candidate genes involved in cellular senescence by a CRISPR/Cas9 screening
Keywords	Cellular Senescence, CRISPR/Cas9
Supervisor/s	Supervisor/s: Mario Encinas
E-mail	mario.encinas@udl.cat
Group	Developmental and Oncogenic Signaling
PhD	Yes


Project:	Validació in vitro de gens implicats en la metàstasi en càncer de còlon
Keywords	línies cel·lulars càncer de còlon, RNAi, assajos proliferació i migració cel·lular, teixit humà, RTqPCR
Supervisor/s	Antonieta Salud Salvia i Eva Parisi Capdevila
E-mail	asaluds@hotmail.com; eparisi@irblleida.cat
Group	Grup de Recerca de Biomarcadors en Càncer
PhD	Yes

Project:	Detecció de biomarcadors tumorals de càncer de pulmó mitjançant biòpsia líquida del líquid pleural
Keywords	biòpsia líquida, càncer de pulmó, vessament pleural, RTqPCR
Supervisor/s	José Manuel Porcel Pérez i Maria Alba Sorolla Bardaji
E-mail	jporcelp@yahoo.es; msorolla@irblleida.cat
Group	Grup de Recerca de Biomarcadors en Càncer
PhD	Yes


Project:	Rare disease discovery: connecting symptoms with genes
Keywords	Genetic Diseases; Computer assisted diagnosis; Genotype to phenotype; Genomic hotspots for disease
Supervisor/s	Rui Alves
E-mail	rui.alves@udl.cat
Group	Biología de sistemas y métodos estadísticos para la investigación
PhD	Yes


Project:	Estudi de l'impacte negatiu de la diabetis mellitus tipus 2 sobre la funció pulmonar i la respiració nocturna
Keywords	type 2 diabetes, sleep apnea, nocturnal hypoxia
Supervisor/s	Albert Lecube
E-mail	alecube@gmail.com
Group	Grup de Recerca en Obesitat, Diabetis i Metabolisme
PhD	Yes

Project:	Obesitat mórbida, cirurgia bariàtrica i predisposició genética
Keywords	obesity, bariatric surgery
Supervisor/s	Albert Lecube
E-mail	alecube@gmail.com
Group	Grup de Recerca en Obesitat, Diabetis i Metabolisme
PhD	Yes

Project:	Diabetis mellitus d'origen autoinmune. Molt més que la diabetis tipus 1
Keywords	autoimmunity, type 1 diabetes
Supervisor/s	Marta Hernández
E-mail	martahernandezg@gmail.co
Group	Grup de Recerca en Obesitat, Diabetis i Metabolisme
PhD	Yes

Project:	Pesticide detection with endocrine disruption function and its relationship with the pregnancy exposome
Keywords	pesticides, endocrine disruptors, exposome, pregnancy
Supervisor/s	Anna Espart
E-mail	anna.espart@udl.cat
Group	Grup de Recerca de Cures de Salut (GRECS)
PhD	Yes


Project:	Precision medicine in patients with sleep apnea and acute coronary syndrome: Predictive model of response to treatment
Keywords	Sleep apnea; Personalized Medicine; Biomarkers.
Supervisor/s	Manuel Sánchez de la Torre
E-mail	sanchezdelatorre@gmail.com
Group	Precision Medicine in Chronic Diseases Group (http://www.irblleida.org/en/research/40/precision-medicine-in-chronic-diseases-group)
PhD	Yes